Mississippi River

THE ANSWER
"Efmo View from Fire Point" — Photo by NPS photo / Wikimedia Commons / Public domain
The great artery of the American heartland.
This river has shaped the landscape and culture of an entire continent. It remains a legendary waterway of commerce and song.
Explanation
Did you know?
Its drainage basin covers over forty percent of the contiguous United States.
The 5 Clues
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“I drain the spirit of a vast continental interior.”
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“My name originates from a language spoken by the riverbank tribes.”
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“I am the protagonist in the adventures of a barefoot boy.”
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“I am the primary channel for the largest drainage system in North America.”
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“I wind my way south to empty into the Gulf.”
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